Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
نویسندگان
چکیده
منابع مشابه
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes, plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis of osteoarthritis and osteoporosis. Chondrocyte proliferation, differentiation, and apoptosis are important steps for endochondral ossification. Although the inactivation of P53 and RB is involved in the pathogen...
متن کاملHypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation.
According to current dogma, chondrocytes and osteoblasts are considered independent lineages derived from a common osteochondroprogenitor. In endochondral bone formation, chondrocytes undergo a series of differentiation steps to form the growth plate, and it generally is accepted that death is the ultimate fate of terminally differentiated hypertrophic chondrocytes (HCs). Osteoblasts, accompany...
متن کاملPrimary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts.
The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isolating primary cultures of osteocytes from chick calvaria, and, using anti-connexin 43 immunocytochemistry, demonstrate gap junction distribution to...
متن کاملAre biological agents toxic to human chondrocytes and osteocytes?
PURPOSE The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. METHODS Primary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as control cultures of chondrocyte and osteocyte, and the other two groups were exposed to BAs administered via the culture medi...
متن کاملThe expression of neurofibromin in human osteoblasts and chondrocytes.
The goal of this study was to determine if neurofibromin is expressed in cultured human osteoblasts and chondrocytes that were isolated from ilia and ilial growth plate. Purity of the osteoblast and chondrocyte cultures was confirmed by alkaline phosphatase and toluidine blue staining, respectively. The reverse transcription-polymerase chain reaction (RT-PCR) was performed to detect neurofibrom...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2016
ISSN: 1422-0067
DOI: 10.3390/ijms17122045